Essay Instructions: 10 pages include
Introduction (5 pages )not including the aim
Method (1 page)
Material (1page)
Discussion (3 pages) of my tables and graphes and how to compare it with other studies
NB I have sent the 6 major referance
articles, and abstract to give you an idea about the subject, I will provide you soon with tables and graphs
INTRODUCTION TO COVER:
1)Sickle cell disease history (from the story of firt discovery in dental student & peculier cell
2)Pathophysiologicaly, SCD is a hemoglobin structure disorder in
which glutamic acid at the sixth residence of the ? chain of hemoglobin
is substituted by valine, resulting in the formation of a poorly soluble
hemoglobin tetramer (?2/?2 S)2. Homozygote (SS) will show clinical
symptoms and heterozygote (AS) or traits are usually asymptomatic.
3) clinical picture
mechanism of sickling & how it causes pain, strok acute chest syndrome
4)SCD complications
The hallmarks of SCD are anemia and vasculopathy. The major
sources of morbidity and mortality in SCD are acute painful syndromes,
severe anemia, infections, acute chest syndrome and organ failure.
5)SCD diagnosis by breif discription of test and finding CBC, blood film, sickling, Hb electrophhoresis, HBLC, DNA analysis, Hb F testing
6)Surgical procedures required IN SCD. SCD types of operations required (Total hip replacement, adenotonsellectomy, laparoscopic cholecystectomy, Lap splenectomy,
7)role of Preoperative blood transfusions: are frequently given to prevent perioperative complications.
There is no consensus, however. on the best regimen for transfusion for
this purpose. Blood transfusion can be life saving and can ameliorate some
of the complications of SCD. Nevertheless, blood transfusions, even when
correctly used, are not without complications3.
8)SCD Types of transfusions required and techniques or methodology (topup or simple transfusion, exchange transfusion EXTX,
Role of HU iSCD pain management and any postoperative effect in SCD
Role of Heparin in SCD management and post op prohpylaxes
Method and material (from abstract given and I will send you a summary (retrospective survey, of 75 patients, we went through medical records and gother information about age, sex, type of operation, type of transfusion, record all pre operative fever, transfuion, vasoocclusive crises, Acute chest syndrom, smoking and the look for the out come including post operative VOC, ACS, fever, lenghth of hospital stay)
Discussion: I will send my tables and graphes for you to comment on the findings and compare them to the 6 articles provided or more articles if you have.
There are faxes for this order.