Search Our Essay Database

Essay Instructions: 1. What are the effects of senescent cells on the aging body, why don't they have the same effects in young bodies?
2. What was surprising in the results of the longitudinal studies of Chambers et al. (and earlier Rossi et al) in which microarray analysis of hematopoietic stem cells revealed that make some people doubt that homeostasis living systems strive for homeostasis?
3. What do the studies of such progerias as Huntington-Gilford progeria and Werner's syndrome tell us about normal aging? Explain
4. Here are three quotes from an printed interview with Francis Collins ,
I. “Collin’s lab team found that in cells growing in the lab, when they used a chemical to un-cap the chromosome ends, it altered gene splicing and led to progerin production and cellular senescence.
II. “It’s clear that progerin turns on as a cell is approaching senescence,” Collins said: Collin’s lab team found that in cells growing in the lab, when they used a chemical to un-cap the chromosome ends, it altered gene splicing and led to progerin production and cellular senescence.
III. “While I can’t prove it, it seems likely that progerin itself is part of normal, programmed senescence,” Collins said. “If we understood that, maybe we would be able to come up with a strategy to deal with the process of normal aging.”
Answer for the following for question# 4 :
a) We've heard that before, that gene splicing alters with age - what does that mean?
b) According to statement ii, they were comparing artificially made senescent cells to the cells of people with what condition?
c) When stating that progerin production is part of normal aging, what theory of aging is he implicitly endorsing?n Why?
5. Describe what you feel are the major 'causes' of aging - and how that fits into what you think is the correct theory of aging.
6. Where would you direct efforts in aging research?
7. Unlike inorganic objects like rocks or even computers (at present), living organisms can repair damage or rebuild or even recycle damages at the cellular. Give three instances cellular systems involved in repairing cellular damages.

8. What is the preferable study group in mammalian testing of aging interventions and explain why. Mice or monkeys? Why?
9. Describe how an enzyme may change the transcription patterns of a cell by adding chemical groups to histone proteins. What is this called?
10. Briefly explain what happened to old stem and progenitor cells in a young systemic environment.

Please answer the following question. The answer shout be short and to the point but have sustenance to it. no more than 2 pages (Please keep the answers short to about 3 sentences max)