Evans, E.G. & Sigurgeirsson, B. (1999, April 17). Double blind, randomised study of continuous terbinafine compared with intermittent itraconazole in treatment of toenail onychomycosis. British Medical Journal, 318, pp. 1031-1036.

Key Points: This study examined the effectiveness of two new medications for the treatment of toenail fungus compared to the current recommended treatment. Both new medicines were found to be more effective.

This was a prospective, randomized, double blind, double dummy, multicenter, parallel group study. The study took place over a period of 72 weeks (about 16-1/2 months) and involved 38 investigators from 35 centres in six different European countries (Finland, Germany, Iceland, Italy, the Netherlands, and the United Kingdom).

Objective: To compare the efficacy and safety of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. Onychomycosis is among the most common diseases of the nail as well as being among the few curable diseases if the...
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