Chen, Ho, Lam, Ho, & Woo, 2003)

The article used for this research is a free full-text manuscript that may be found on PubMed.

The purpose of the present study was to investigate the effects of dietary intake of soy isoflavones on bone loss in postmenopausal women. Subjects were aged 48 to 62 years and within 10 years of natural menopause. Exclusion criteria for this study included any diseases or medications, including use of exogenous estrogens, corticosteroids, thiazine, or any medication known to effect bone mass. This trial was a double-blind, placebo-controlled, randomized study that examined two doses of isoflavones (40 mg and 80 mg daily) and placebo on bone mass maintenance in early postmenopausal women. The alternate hypothesis of this study was that dietary isoflavone supplementation would prevent bone mineral loss in early postmenopausal women.

Subjects in the three intervention arms of the study had similar demographic characteristics. Annualized...
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