[Pedrazzoli et.al, 2004]

While the above study discussed changes in levels of beta-adrenergic receptors, a research by Hip lide et.al studied the effects of REM deprivation on the binding changes among ?1-, ?2-, ?1- and ?2 adrenergic receptors in different regions of the brain. All the 91 rats used in the study were sleep deprived for 96 hours prior to the experiment. It was observed that the binding of [3H] prazosin to the ?1 receptors was not considerably different along the different regions of the brain but a mild reduction was observed. Similarly there was no significant difference in the binding to ?2 sites labeled as [3H] UK-14, 314 in all of the 91 observed areas but it showed a mild increase. However, the ?1- and ?2 receptors showed considerable reduction in binding. Data gathered using quantitative receptor autoradiography revealed that atleast in 13 of 69 brain regions, ?1 receptor...
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