123). In this study, Martinez-Contreras and her associates report the results of recent research that has provided additional evidence concerning the function of these proteins in precursor-messenger RNA (pre-mRNA) splicing (2007).

The splicing repression can function in two discrete ways in heterogeneous nuclear RNP proteins; the first way is by antagonizing the recognition of splice sites directly and the second way is through interference with the binding of proteins that are bound to enhancers (Martinez-Contreras et al., 2007). A growing body of research concerning the role of hnRNP proteins has determined that these proteins can restrict communication between factors bound to different splice sites; by contrast, a number of studies have identified a positive role for some hnRNP proteins in pre-mRNA splicing (Martinez-Contreras et al., 2007). Moreover, the research to date suggests cooperative interactions between bound hnRNP proteins that may facilitate splicing between specific pairs of splice sites while concomitantly...
[ View Full Essay]