Alternatively, degeneration of the ascending cholinergic and catechola- minergic neuronal systems may contribute, at least in part, to the occurrence of this frontal-lobe-like symptomatology associated with Parkinson's disease. (Dubois & Pillon, 1996, pp.2-8)

The development of a greater understanding, over time of the causal factors as well as the manifestations and possible interventions for cognitive function in Parkinson's disease has continued since this time. Greater functional understanding of neurotransmitters and receptors as well as brain function in general have also significantly aided in the treatment Parkinson's Disease. Research has even led to the conclusion that standards dopamine (pharmacological) treatments while they improve some cognitive function (switching between two tasks "thought to depend on circuitry connecting the dorsolateral prefrontal cortex and the posterior parietal cortex to the dorsal caudate nucleus) might impair others that are usually spared by PD (probabilistic reversal learning, which; "implicates orbitofrontal cortex -- ventral striatal circuitry." involvement)...
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