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Essay Instructions: Gene technology carries with it social and ethical implications?many of which engender personal views
and discussion.

Write a three (3) page paper in which you:

1. Select one (1) of the following biotechnology topics to explore, providing a sound rationale for your selection:

? Genetically modified crop plants

? Genetically modified microorganisms

? Genetically modified animals

? Personal genomics and / or personalized medicine for humans

? Gene therapy

2. Organize your paper into the following three (3) sections.

a. Biological basis. Describe the technology. Discuss what it accomplishes. Elaborate on the scientific principles that make this technology possible. Describe how exactly the technology works. Discuss the biological principles that underlie this technology.

b. Social and ethical implications. Without disclosing your personal view about this technology, provide an analysis of its social and ethical implications. State the ethical concerns apparent in the use of this technology. Discuss the benefits and risks. Your goal in this section is to look at all sides of the issue. In the next section, you will give your opinion.

c. Personal viewpoint. In the previous section, your goal was to be as objective as possible, to look at all sides of the issues. In this section, your goals are to give a personal opinion about the technology and provide a justification of that opinion.

3. Use at least three (3) quality resources in this assignment. Note: Wikipedia and similar Websites do not qualify as quality resources. The body of the paper must have in-text citations that correspond to the references.

Essay Instructions: Required

McCance, K. A. & Huether, S.E. (2010). Pathophysiology: The biologic basis for disease in adults and children (6th ed).
Chapters 4 and 5
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Assignments

Exercises: (10 points each)
8. What roles do genes play in determining cell structure and function? How is gene expression regulated?
9. What is the role of the environment in development of congenital disorders?
10. How might 1) overexpression of proto-oncogenes and 2) underexpression of tumor suppressor genes lead to abnormal cellular proliferation?
11. Describe a teaching strategy to explain DNA replication and protein synthesis
12. You have been asked to counsel a family in which the father has Neurofibromatosis. Explain why autosomal dominant disease penetrance can vary from one family to another.
Professional Development (20 points each)
13. Choose one of the genetic disorders discussed or listed in one of the tables in your textbook. Perform a literature search in a database of professional journal articles to find current, reliable information about the disorder. Write a summary that presents the genetic defect, details of its molecular basis, and its clinical manifestations. Include at least two references beyond your textbook. Use Cri du chat

14. Multifactorial inheritance has been shown to influence the development and expression of a number of disease conditions. Conduct an in-depth review of existing literature and describe how twin and adoption studies have enhanced our knowledge about multifactorial inheritance. How would you use this information to counsel a client about breast cancer, colon cancer, or diabetes risk?

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Essay Instructions: an annotated bibliography of new approaches to management and treatment of sickle cell disease including advances in gene therapy, 8 key resources need to be identifies ant at least 6 should be primary sources, a review can be included plus a textbook or website review, the annotations themselves need to be 50-100 words, and there needs to be included a critical overview of the topic drawing on the references highligted in the above annotated bibliography.

Essay Instructions: My topic is gene therapy and FDA regulations . In this paper I describe past and current status of gene therapy, Investigational new drug application, guidance from CBER and other regulatory framework regarding clinical trials for gene therapy.

I want you to write in the paper requested write about your opinion the complexity of gene therapy products and the cause behind the non approval of any gene therapy product in the US. My suggestions for the betterment of the existing framework and the potential areas of improvement. Positive points from other nations regulations of gene therapy that can be integrated in USFDA gene therapy regulation