Essay Instructions: Meta-Analysis of Fibromyalgia Treatment
The following is a list of requirements for a concept paper and forthcoming dissertation quality research paper.
A list of required topics for the dissertation quality research paper that must be investigated include: (Highlighted portions are for the concept paper, which are to be incorporated into the dissertation at a later date ? See attached Fibromyalgia research for assistance). Concept paper information is to be fairly brief and basic in scope and depth. Graphs and/or charts may or may not apply for concept paper, but will be specified in later research investigation on this topic.
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I will also email/reply to an email from "Jayson" with this list in Word, which has highlighted portions. I will also email additional documentation, as it will be too long to fax.
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Historical Evolution of Fibromyalgia (FM): (General and/or Basic understanding for the purposes of the concept paper)
1. When was the first diagnosis of FM made and what was it then known as?
2. How far do symptoms and formerly diagnoses of FM go back into history?
3. Who were the major contributors to FM becoming discovered, when and where?
4. What was the etiology / genesis of FM?s history from myth to medical ?fact??
5. How was it / is it diagnosed then?
6. When was the first time FM was introduced into Medical Schools (1992) and where, by who?
7. Who was the typical patient diagnosed with FM and has it changed?
8. What psychological, sociological, anthropological, physiological, neurological, and familial etiologies / genesis of FM components existed and what were the possible relationships and/or links to each of these co-existing/co-morbid systems?
9. Any other historical information that can be helpful to the understanding of FM.
Present Understanding of FM: (Again General Concept for the Concept Paper)
1. What are the current standards of diagnosis?
2. Explain thoroughly (briefly for concept paper) the 18 tender points associated with FM and what there physiological and neurological pathways are (presently known/thought of pathways), as they relate to the pain signals that are relayed to the brain. How does the brain (to the best of our knowledge) receive a pain signal from these tender points?
3. What is the role of collagen in FM? (Collagen is the sticky stuff between joints and muscles, which helps the joint fight against friction, causing pain when collagen is not present as a buffer between joints and muscles).
4. FM is a collagen disorder, but what is collagen and why do we need it? (briefly for Concept Paper)
5. What is the role of sleep on FM and how does it affect collagen?
6. Explain the 4 stages of sleep, including REM sleep and what chemicals are released into the body in what stages of sleep? Also, where in the brain these chemicals come from and what path they take, if possible. (This is a crucial piece to the understanding of the role of sleep on FM).
7. Explain as specifically as possible the chemicals that are thought to play an important role in FM (Somatomadin-C and Substance-P for example).
8. How is this important in FM?
9. What theoretical/factual role do these chemicals released in stage-4 sleep (Somatomadin-C, among other restorative sleep chemicals) play in FM?
10. What is Substance-P and how is it important in FM? How do we test for it and what does it tell us and why? (test for it in blood, based on levels it exists?)
11. Why is sleep so important in FM?
12. Why are sleep aids (sleeping pills / medications) generally not effective for FM (they only increase quantity, not quality of sleep)? Site articles that come close to even supporting this.
13. What symptoms are specific to FM and what is the typical manifestation of FM symptoms?
14. Who typically gets diagnosed with FM, why do we think this is?
15. What is the trend of FM and what theories have been developed on what FM is and how to ?cure? it?
16. What medications are typically effective with FM?
17. Why and how do they work?
18. What systems do they work on and what is there to be known about the medications, i.e. general side effects, action potentials, routes of metabolism, etc.?
19. What is unknown about the medications used in general, which is specific to all medication limitations (action potential unknown for many medications, therefore side effect profile can be problematic)?
20. Explain the limitation often overlooked in medication research as compared to psychological research, i.e. double blind studies are often inappropriate for psychologically based studies.
21. What biases are often present with medication research? (See November / Winter Issue of Journal of Neurotherapy by snr-jnt.org ? The Society of Neuronal Regulation and the Journal of Neurotherapy. This is an editorial by the outgoing President of iSNR).
22. What other remedies have been and are currently reported in the literature as possible effective treatment modalities, i.e. biofeedback, yoga, exercise, and other nutritional remedies, etc.?
23. How and why do we think they are effective?
24. What role do we think they play in reducing the symptoms associated with FM?
25. What about Quantitative Electroencephalogram (qEEG) and Neurofeedback?
26. What emerging role do they play as reported in the literature? (see Donaldson?s research out of Canada for at least one reference from the journal of pain management).
27. Why is it proposed that they (emerging treatment modalities) may have some effectiveness in the diagnosis and treatment of FM?
28. What studies have been published at all with regard to standard EEG?s, qEEG (quantitative), and/or Neurofeedback?
29. Are they promising?
30. Why, what do they offer?
31. What theoretical underpinnings might exist with regard to the link between brainwaves and FM?
Historical Perspective of Electromyogram (EMG or muscles) and Electroencephalogram (EEG or Brainwaves) to Present Understanding:
1. What is EMG and what is the difference between surface EMG (sEMG)? (basic understanding will suffice)
2. How are EMG recorded and what role does the recording of standard EMG play? (they are typically invasive procedures and painful - again general understanding).
3. How is it related to general EMG-Biofeedback or what is often called sEMG (surface EMG)?
4. How has Biofeedback been used for FM?
5. Has it been proven effective and/or useful as demonstrated in the literature?
6. Who are the major contributors to EMG-Biofeedback and its application to FM?
7. What is the general conceptual understanding of how Biofeedback works?
8. How does Biofeedback basically differ from Neurofeedback? (Muscle feedback as compared to brainwave feedback)
9. What are brainwaves?
10. What is the general understanding of the role brainwaves play in humans? (why are they important to understand?) Theoretical framework.
11. How are they recorded?
12. What measurements are used and why? (Power, Amplitude, Percent Power, etc.)
a. See qEEG interpretations for a more comprehensive look at how brainwaves are viewed in their different mathematical underpinnings. Robert Thatcher?s work which can be seen at www.appliedneuroscience.com
13. What is the history of brainwaves?
14. When was the first brainwave recorded? (about 150 years ago)
15. what are the general criticisms of brainwave recordings and/EEG-Biofeedback / Neurofeedback in general? (how do we know what to make of them and how do we know that they are consistent throughout the life span, etc.
16. What is the proposed usefulness generally accepted by the medical community for recording brainwaves? (seizure activity and evoked potentials in standard EEGs?, etc.)
17. Who are some of the pioneers in brainwave research and more specifically Neurofeedback or EEG-Biofeedback research? (Joe Kamia Univ. of Chicago, Joel Lubar Univ. of Tenn., Barry Sterman UCLA, etc.)
18. Who are some of the pioneers with regard to EEG-Biofeedback, EMG-Biofeedback and FM? (Stu Donaldson out of Canada, etc.)
19. What research has been published with regard to the efficacy of Neurofeedback, Neurotherapy, and/or EEG-Biofeedback (all synonymous)?
20. What is qEEG?
21. What is the history of qEEG?
22. What is the importance of qEEG and how does it differ from standard EEGs? (standard EEGs only record individual sites, whereas qEEG records individual sites and compares them to each other, which helps to determine how well or not so well the brain communicates with itself, among other reasons).
23. What research has been done on the efficacy of qEEG and how has it evolved?
24. Who are some of the pioneers in the field of qEEG?
25. What research is available on qEEG and FM? (Stuart Donaldson out of Canada is a major contributor to qEEG, Neurofeedback and General Biofeedback?
26. What are all of the ways in which qEEG is measured and what do the difference mathematical calculations of the qEEG data generally mean? (co-modulation, coherence, synchrony, phase, power, percent power, amplitude, etc., again www.appliedneuroscience.com and R. Thatcher?s work).
27. What research is available to support the validity of qEEG data and who are some of the major contributors of qEEG research? (Dr. Duffy out of Harvard, Dr. Daniel Amen, Dr. Joel Lubar Univ. of Tenn., Dr. Barry Sterman UCLA, etc.)
28. What are some of the general emerging applications that qEEG is being used for?
29. Why might it be important for FM research, at least according to Stuart Donaldson out of Canada?
Meta-analysis comparing most popular treatments for FM, as well as compared to Biofeedback and most importantly qEEG and Neurofeedback / EEG-Biofeedback:
1. Explain the general principals and dynamics of a meta-analysis and why it should be used for this type of comparative analysis with regard to how the most popular approaches to treatment stack up against each other, as well as compared to Neurofeedback / EEG-Biofeedback?
2. What are limitations, pros and cons for this type of analysis?
3. Explain what the research indicates about how close or far apart some treatment approaches really are from others?
4. What might contribute to limitations of any study included into the studies investigated here?
5. What are the conclusions of what might be/was found with regard to research available in this meta-analysis?
General Conclusions & Summary:
1. What is/was the overall purpose of this investigation? (to understand more thoroughly what research was available with regard to FM and how effective was any one treatment approach over another).
2. General conclusions about restatement of the problem, what was investigated, how, and what was the overall conclusion?
3. What are/were the limitations of this investigation?
4. What might be a better approach to investigating FM research and efficacious treatment modalities used to treat the symptoms of FM?
5. What direction might be next and of course there is a need for further research in this area?
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General Sections of the Concept Paper include the following:
A. Introduction
B. Statement of the Problem
C. Brief Overview of the Literature
D. Methods
E. Limitations of the Study
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Concept paper should be 15 pages with approximately 20-30 references.