Efficacy and Safety of Oral Insulin Analogs Research Paper

Efficacy and Safety of Oral Insulin Analogs

Oral Insulin Analogs and Gestational Diabetes

Efficacy and Safety of Oral Insulin Analogs during Pregnancy

The promise of better glycemic control and patient treatment compliance is offered by oral insulin analogs (Lee-Parritz, 2012). In the United States and Europe, the most common insulin analogs used to treat pregnant women are the sulphonylureas glyburide and glibenclamide, and the biguanide metformin (Nicholson and Baptiste-Roberts, 2011). Most studies examining the efficacy and safety of insulin analogs have relied on gestational diabetes patients, therefore there has been little data generated using type II pregestational diabetes patients.However, Lee-Parritz (2012) assumes the successful use of these drugs in patients with gestational diabetes should not deter physicians from turning to these drugs when treating pregestational diabetes.

A recent meta-analysis of six randomized, controlled studies, having a combined subject pool of 1388 patients, compared insulin to oral insulin analogs (glyburide and metformin) in terms of infant and maternal health outcomes (Dhulkotia, Ola, Fraser, and Farrell, 2010). Overall, maternal glycemic control, infant hypoglycemia, macrosomia,….....